The closest A.thaliana genes, according to BlastP, are the AceView genes AT3G30665 (e=0.64), tuder (e=0.84)
It has been described as Z-DNA-binding protein 1, DNA-dependent activator of IRFs, tumor stroma and activated macrophage protein DLM-1, DNA-dependent activator of interferon regulatory factors.Ĭlosest AceView homologs in other species ? The closest mouse gene, according to BlastP, is the AceView gene Zbp1 (e=3 10 -19). Other names: The gene is also known as ZBP1, DAI, DLM1, DLM-1 or C20orf183, LOC81030.
Links to: manual annotations from KEGG_04623, the SNP view, gene overviews from Entrez Gene 81030, GeneCards, expression data from ECgene, UniGene, molecular and other annotations from UCSC, or our GOLD analysis.
Map on chromosome 20, links to other databases and other names Map: This gene ZBP1 maps on chromosome 20, at 20q13.31 according to Entrez Gene. Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12. The remaining 2 mRNA variants (2 unspliced 2 partial) appear not to encode good proteins. Protein coding potential: 10 spliced mRNAs putatively encode good proteins, altogether 10 different isoforms (6 complete, 3 COOH complete, 1 partial), some containing Adenosine deaminase z-alpha domain. Proteins are expected to have molecular functions (left-handed Z-DNA binding, double-stranded RNA adenosine deaminase activity, RNA binding) and to localize in membrane. Functionally, the gene has been proposed to participate in pathway (Cytosolic DNA-sensing pathway). The mRNAs appear to differ by truncation of the 3' end, presence or absence of 2 cassette exons, overlapping exons with different boundaries, splicing versus retention of one intron.Ģ variants were isolated in vivo, despite the fact that they are predicted targets of nonsense mediated mRNA decay (NMD).Įfficacy of translation may be reduced by the presence of a shorter translated product ( uORF) initiating at an AUG upstream of the main open reading frame (in variant fAug10).įunction: There are 11 articles specifically referring to this gene in PubMed. There are 2 probable alternative promotors, 4 non overlapping alternative last exons and 4 validated alternative polyadenylation sites (see the diagram). Transcription produces 12 different mRNAs, 10 alternatively spliced variants and 2 unspliced forms. We annotate structural defects or features in 2 cDNA clones.Īlternative mRNA variants and regulation: The gene contains 14 distinct gt-ag introns. The sequence of this gene is defined by 52 GenBank accessions from 47 cDNA clones, some from colon (seen 3 times), small intestine (3), cervix, tumor tissue (2), esophagus (2), spleen (2), squamous cell carcinoma (2), t-lymphocytes (2) and 16 other tissues. Note that this locus is complex: it appears to produce several proteins with no sequence overlap.Įxpression: According to AceView, this gene is well expressed, 0.4 times the average gene in this release. e), but Homo sapiens cDNA sequences in GenBank, dbEST, Trace and SRA, filtered against clone rearrangements, coaligned on the genome and clustered in a minimal non-redundant way by the manually supervised AceView program, support at least 10 spliced variants.ĪceView synopsis, each blue text links to tables and details RefSeq annotates 4 representative transcripts (NM included in AceView variants. Z-DNA formation is a dynamic process, largely controlled by the amount of supercoiling.